We specialize in sterile filling operations, developing and manufacturing both formulation vessels and applications systems. Various construction forms make it possible to achieve a filling volume of 10m³. The systems include mobile or fixed formulation vessels with different media connections for WFI, medication, air, etc. Thus the medication can be formulated and filled into different containers (syringes, bottles, bags). The system can be equipped with heating or cooling jackets, insulation, and can thus be manufactured specifically for your needs.

Formulation vessels can be equipped with various fittings, such as

  • sterile filters,
  • transfer ports,
  • manholes,
  • magnetic stirrers,
  • sight glasses,
  • measurement systems (e.g. temperature and pressure)
  • CIP balls,
  • insulation,
  • heating and cooling jacket,

PROCESSING SYSTEMS

Microbial Bioreactors 

  • 10 L up to 30.000 L volume
  • With top or bottom agitator
  • With single or double mechanical seal agitator
  • Automated CIP, SIP
  • cGxP compliant
  • full control, PAT
  • fully customized to clients requirements

Cell Line Bioreactors

  • Optionally with Perfusion (ATF or TFF)
  • From 10 L up to 20.000 L volume
  • With magnetic agitator
  • Automated CIP, SIP
  • cGxP compliant
  • Full control, PAT
  • fully customized to clients’ requirements

Media and buffer preparation

  • efficient mixing
  • automated CIP, SIP
  • with media distribution
  • system can be separated in technical and clean room area
  • cGxP compliant
  • fully customized to clients’ requirements

Process vessels and systems

  • for biochemical and chemical reactions
  • vacuum systems
  • different mixing solutions available
  • double wall, half pipe or pillow plate
  • cGxP compliant
  • fully customized to clients’ requirements

Filtration

  • microfiltration
  • ultrafiltration / diafiltration
  • nanofiltration
  • depth filtration
  • using filter type by client choice
  • footprint adjusted to required space
  • cGxP compliant
  • fully customized to clients’ requirements

Chromatography

  • batch chromatography
  • with or without HETP test
  • slurry vessels
  • for resin or membrane column
  • footprint adjusted to required space
  • cGxP compliant
  • fully customized to clients’ requirements

Mobile vessels

  • volumes up to 1600 L
  • different mixing solutions available
  • connection to a central CIP, SIP and DIP module
  • use of retractable washing heads for CIP
  • automated dosing of ingredients and weighing
  • cGxP compliant
  • fully customized to clients’ requirements

Clean utilities, CIP and COP systems

  • water for injection
  • purified water
  • clean steam
  • pure gas system
  • CIP skids
  • Brinox Cleaning Systems
  • Fully Automated units
  • Can be offered with storage and distribution
  • cGxP compliant
  • fully customized to clients’ requirements